Xinhua news agency, Beijing, January 24 (Xinhua News Agency reporter Dong Ruifeng) – Chinese scientists race against time to identify the pathogen and actively share the gene sequence of the new coronavirus with the international community, so as to win precious time for the world’s epidemic prevention and control work such as diagnosis reagent design, drug screening, vaccine development and virus traceability.
The first batch of novel coronavirus pneumonia specialists who faced the new crown pneumonia epidemic were interviewed in a review of the battle against the virus.
&If we don’t know about the virus, it’s like we can’t find the enemy in the battlefield. &”Wu Guizhen, chief biosafety expert of CDC, said. On January 2, 2020, after receiving the case specimens from Hubei Province, Wu Guizhen, team Tan Wenjie and team Zhao Xiang from the Institute of Virology of the Chinese Center for Disease Control and prevention immediately put into a “relay race” to decipher the genetic code of the virus;.
According to the expert’s judgment, the National Health Commission organized many institutions with high-level biosafety laboratory conditions, such as the China Center for Disease Control and prevention, the Chinese Academy of Medical Sciences, and the Wuhan Institute of Virology, Chinese Academy of Sciences, to carry out pathogen identification in parallel.
In order to understand the full picture of the virus most quickly and accurately, the Institute of Virology of CDC has made an overall layout, with the emergency technology center as the core, combined with the biological safety level 3 Laboratory of the Institute of Virology, the National Influenza Center and the central instrument room to tackle key problems. At the same time, the whole genome sequencing work has been carried out in an all-round way by using the first-generation sequencing, second-generation sequencing and third-generation sequencing technologies.
Also on January 2, 2020, the Chinese Academy of Medical Sciences received the first batch of samples from Hubei Province, and then began to analyze the samples. It was found that the same unknown coronavirus sequence existed in the microbiome sequences obtained from the samples, and the coronavirus sequence was the main viral sequence, and no other clear pathogenic information associated with acute respiratory infection was found.
Zhou Peng, a researcher at Wuhan Institute of Virology, Chinese Academy of Sciences, said that as a professional virus research institution with high-level biosafety laboratory, Wuhan Institute of Virology immediately organized scientific researchers to work on scientific research after receiving samples of unexplained pneumonia cases from Wuhan Jinyintan hospital, mainly carrying out virus genome sequencing, virus isolation and virus specificity test The establishment of measurement method.
Genome sequencing in parallel with several laboratories revealed that the same New Coronavirus genome sequence was found in the samples, and the genome sequence did not exist in healthy people and other types of pneumonia. A key step was taken to identify the pathogen.
While sequencing the genome, scientists are also racing against the clock to carry out virus isolation. Virus isolation is the gold standard for pathogen diagnosis, and it is also one of the most critical evidences for epidemic research and judgment. Considering the complexity of virus isolation, in order to improve the success rate of virus isolation, they use a variety of virus isolation strategies at the same time. In January 7, 2020, China CDC first used &ldquo under electron microscope; captured ” the arch criminal of epidemic situation — — typical coronal shape, with crown like outer layer particles of New Coronavirus.
On January 8, 2020, the expert evaluation group of the National Health Commission preliminarily confirmed the new coronavirus as the pathogen of the epidemic after considering the evidence of genome sequencing, successful isolation of the virus, obtaining electron microscope photos of the virus, highly consistent etiological detection and clinical diagnosis. In January 9th, the expert evaluation team of the national health and Health Committee released the pathogen information of unknown causes of viral pneumonia in Wuhan. The pathogen was initially identified as New Coronavirus. China informed the World Health Organization of the epidemic situation and shared the preliminary progress in pathogen identification with who.
&The initial identification of the virus in such a short period of time is a remarkable achievement. &”Who website evaluation on the same day.
Based on further comparison and verification of multiple samples, in January 12, 2020, the China Disease Control Center, the Chinese Academy of Medical Sciences and the China Academy of Sciences Wuhan virus served as the designated body of the national health and Health Commission to submit New Coronavirus genome sequence information to who, and to publish the global influenza sharing database and share it globally. The National Health Commission shares information on the genome sequence of the new coronavirus with who.
This means that the world can share these source information, so as to develop detection reagents, develop vaccines, etc., and confront the virus head-on;. In this race against time, Chinese scientists have provided key information for global epidemic prevention and control with a scientific and rigorous attitude and professionalism.