How is uterine myoma caused
The exact cause of hysteromyoma is unknown. The occurrence and development of hysteromyoma are multi factor and multi link. At present, it is generally considered that hysteromyoma is a sex hormone dependent tumor. In addition, the incidence of hysteromyoma may be related to age, obesity, pregnancy history (abortion history), smoking, drinking, genetic factors and other factors.
Causes of uterine fibroids
The factors of uterine fibroids include the following three categories:
1、 General factors:
1. Age: uterine leiomyoma occurs in women of childbearing age, mostly in women aged 30-50, rarely in adolescent women with uterine leiomyoma, postmenopausal uterine leiomyoma atrophy or regression.
2. Obesity: obesity can cause metabolic disorders, lead to lack of periodic regulation of progesterone, cause abnormal menstrual cycle, affect ovulation, increase the risk of uterine fibroids.
3. History of pregnancy and abortion: women with a history of pregnancy and childbirth are more likely to suffer from uterine fibroids than women without a history of pregnancy and childbirth, and the age of onset is earlier, mainly because of the increase of progesterone in women’s body through production capacity.
4. Smoking, drinking: smoking and drinking are easy to induce uterine fibroids. Studies have shown that women who smoke one pack a day are six times more likely to suffer from uterine fibroids than non-smoking women.
2、 Hormone level: 1
1. High estrogen: biochemical detection confirmed that the estrone conversion of estradiol in leiomyoma was significantly lower than that in normal muscle tissue, and the concentration of estrogen receptor in leiomyoma was significantly higher than that in peripheral muscle tissue. Therefore, it is considered that the local high sensitivity of leiomyoma to estrogen is one of the important factors in the occurrence of leiomyoma.
2. Progesterone is high. Progesterone can promote the mitosis and stimulate the growth of myoma. If the female body progesterone level is high, it is easy to induce uterine fibroids.
3、 Genetic factors:
Cytogenetics showed that 25% – 50% of uterine fibroids had cytogenetic abnormalities, such as chromosome segment position exchange, chromosome long arm rearrangement or partial deletion. Uterine leiomyoma is formed by proliferation of monoclonal smooth muscle cells, and multiple uterine leiomyoma is formed by different clonal cells.